Basic Biology of Aging at the University of Washington

Training Grant Faculty

Director:

Peter S. Rabinovitch, Professor, Director of the Genetic Approaches to Aging Research Training Grant and Director of the Nathan Shock Center of Excellence in the Basic Biology of Aging 

Executive Committee:

Matt Kaeberlein, Associate Professor, Co-Director of the Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Healthy Aging and Longevity Research Institute (HALo), Executive Committee of the Genetic Approaches to Aging Research Training Grant 

David Marcinek, Associate Professor, Radiology, Executive Committee of the Genetic Approaches to Aging Research Training Grant

Daniel Promislow, ProfessorDirector Canine Longevity Consortium, Executive Committee of the Genetic Approaches to Aging Research Training Grant

Rosa Ana Risques, Assistant Professor, Pathology, Executive Committee of the Genetic Approaches to Aging Research Training Grant

May J Reed, Associate Professor, Gerontology & Geriatric Medicine, Executive Committee of the Genetic Approaches to Aging Research Training Grant

Faculty:

Member Affiliation Research Relevant to the Program

Peter S. Rabinovitch
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Pathology, Director Genetic Approaches to Aging Training Grant Mitochondrial dysfunction in aging, particularly cardiac aging, and targeted healthspan extending interventions
William Banks
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Medicine, Division of Gerontology Blood-brain barrier changes in aging and Alzheimer's disease; neuroinflammation; CNS oxidative stress; Drug delivery to the brain
Pamela Becker
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Medicine, Division of Hematology

Age related changes in acute myeloid leukemia, aging of hematopoietic stem cells and the bone marrow microenvironment

Jason Bielas
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Fred Hutchinson Cancer Research Center, UW Pathology Nuclear and mitochondrial DNA mutations in aging and cancer

Kevin Conley
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Physiology & Biophysics, Bioengineering Sarcopenia of aging and muscle energetics studied using in vivo molecular tools, including MRI

Dave Cook
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Pharmacology, Medicine Geriatric neurodegeneration and the dyshomeostasis of the glutamatergic neurotransmitter system and insulin

Christine M. Disteche
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Pathology Epigenetic control of gene expression and gene inactivation/reactivation

Maitreya Dunham
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Genome Sciences Yeast evolutionary genetics, nutrient limitation and aging
Jose Garcia
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Gerontology Age-related sarcopenia and body weight regulation.

Richard Gardner
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Pharmacology Proteostasis and the age-dependent accumulation of structurally aberrant, aggregation-prone proteins
Alan Herr
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Pathology Mutation accumulation and aging

Matt Kaeberlein
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Pathology Genetic determinants of lifespan and dietary restriction

Terrance J. Kavanagh
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Environmental Health Oxygen free radicals, glutathione metabolism in aging and response to environmental toxicants
C. Dirk Keene
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Pathology, Neuropathology

Innate immune response in the aging brain and retina, identifying key genes and pathways involved in degenerative diseases such as Alzheimer’s disease, Parkinson’s disease and glaucoma

Scott Kennedy
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Pathology Somatic mutations in driving aging and neurodegenerative diseases
Deok-ho Kim
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Bioengineering Performance of muscle cells and response to therapy using induced pluripotent stem cells from young and old patients

Mary-Claire King
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Genome Sciences Genetic polymorphisms and disease, including polymorphisms in the Werner Syndrome gene WRN

Brian Kraemer
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Medicine, Division of Gerontology

Identifying mechanisms to control aging dependent protein aggregation and resulting neurotoxicity

Warren Ladiges
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Comparative Medicine  Dr. Ladiges' research focuses on the investigation of pathological mechanisms of aging with a specific interest in the preclinical testing of anti-aging drugs in aged mouse models for translational relelvancce to clinical aging studies and chrinic diseases of the elderly.

Lawrence A. Loeb
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Pathology
DNA replication fidelity, aging and cancer

Michael MacCoss
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Genome Sciences Proteomic approaches to aging and aging-related diseases in model systems

Nancy Maizels
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Immunology Recombinational mechanisms of genetic instability in Werner Syndrome and RecQ helicase deficiencies

David Marcinek
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Radiology, Adjunct Bioengineering In vivo mitochondrial energetics and dysfunction in aging muscle

George Martin
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Pathology, Genome Sciences Stochastic mechanisms of aging
Alexander Mendenhall
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Pathology Stochastic variation in the aging process; C. elegans aging.

Dana Miller
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Biochemistry Hypoxia, nutrient depletion and hydrogen sulfide effects on metabolism and longevity

Sheri Mizumori
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Psychology Neurophysiology of learning, memory, and decision making in aging

Raymond J. Monnat
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Pathology, Genome Sciences Werner syndrome, RecQ helicase deficiencies, genetic instability and metabolic response to DNA damage
Jim Olson
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Fred Hutchinson Cancer Research Center, UW Pediatric Hematology/Oncology Gene expression programs controlling neural differentiation, brain tumor genesis, and neurodegenerative diseases

Leo Pallanck
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Genome Sciences Mitochondrial quality control; Drosophila models of neurodegeneration models of neurodegeneration
Elaine R. Peskind
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Psychiatry Cerebrospinal fluid biomarkers in aging and Alzheimer’s disease, mild traumatic brain injury as a risk factor for neurodegenerative dementing disorders
Daniel Promislow
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Pathology, Biology
Genetic variation in Drosophila, metabolomics, age-specific mate choice, evolution of aging, and the Dog Aging Project

May J. Reed
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Medicine/Geriatrics Extracellular matrix, angiogenesis and aging
Rosa Ana Risques
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Pathology Telomeres and mutations in the interface between aging and cancer

Rong Tian
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Anesthesiology, Adjunct Biochemistry Cardiac metabolism and mitochondrial energetics
Judit Villen
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Genome Sciences Proteomic studies of cellular signaling and protein homeostasis in aging and age-related diseases

Tom Wight
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Pathology Vascular disease, extracellular matrix and laminopathy in Hutchinson Gilford Progeria
Andrea Wills
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Biochemistry Age-dependent decline in the regenerative abilities of vertebrate tissues

Zipora Yablonka-Reuveni
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Biological Structure Myogenic stem cells and satellite cells in aging skeletal muscle
Jessica Young
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Pathology Elucidating Molecular Phenotypes of Late-Onset, Sporadic Alzheimer’s Disease using Human Induced Pluripotent Stem Cells
J. Zhang
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Pathology Biomarkers for Alzheimer’s disease and Parkinson’s disease, with emphasis on clinical applications and mechanisms involved