Genetic Approaches To Aging Training Grant

Supporting pre- and post-doctoral trainees through an NIA Training Grant.

Program Description

The goal of our program is to train new independent investigators who will utilize contemporary genetic and molecular genetic techniques to investigate the underlying mechanisms of aging. The tools for the molecular genetic approach to the pathobiology of aging are becoming increasingly rich and diverse. We believe that this focus for gerontological research will be applied with increasing frequency and success, and that it is essential for our new investigators to be trained in their use.

Our faculty members are highly productive and interactive research investigators whose proficiencies encompass gene cloning and transfer, mutagenesis, DNA sequencing, utilization of conventional and ES cell-derived transgenic mice, and genetic linkage analysis. They are applying these approaches to analysis of fundamental cellular processes, such as DNA replication and repair, gene expression, cell cycle control and programmed cell death. In doing so, they will better understand the how these contribute to cellular and organismal aging. They work on a wide range of organisms amenable to genetic analysis, ranging from E. Coli to yeast, to C. elegans, to mouse and man.

We have in place a dynamic, comprehensive training program that brings together the disciplines of genetics, molecular genetics and fundamental gerontological research. We have excellent investigators in these fields who collaborate extensively. Our faculty includes both senior members who have extensive experience in training predoctoral and postdoctoral students as well as newer members whom we believe are future leaders in aging research. The didactic component of this program is organized around a Basic Biology of Aging Seminar and Proseminar course. Expertise in molecular genetics is taught predominantly by hands-on research in dynamic laboratories. All of our trainees carry out their research and didactic studies in an environment that regularly brings to their attention the exciting opportunities to apply genetic approaches to problems in gerontology.

Positions are available now. If interested, please see the application procedure.