Basic Biology of Aging at the University of Washington

Nathan Shock Center Cores

Resources Cores

The Nathan Shock Center supports three resources cores that provide services to the gerontology community for the development of transgenic animal models, the applications of cytometry and cell sorting, and the study of alterations in gene expression and proteomics.

  • Transgenic Animal Model Development Core 
    • Warren Ladiges, Director
    • Generation of conventional and allele replacement transgenic mouse models for studies of the biology of aging
    • Assistance with study design and aging rodent colonies for studies of aging  
  • Functional Assessments Core 
    • Peter Rabinovitch, Director
    • A comprehensive panel of physiologic and functional tests for the assessment of mouse "healthspan"
    • An array of cellular assays for assessment of aging phenotypes, including flow cytometry and cell sorting, image cytometry and telomere analyses
    • Pathology for analyses of mice used in studies of the biology of aging
  • Functional Genomics Core 
    • Michael MacCoss, Director
    •  Proteomics, including measurements of proteome abundance and turnover Transcriptomics, including transcriptional arrays and Translational State Array Analysis (TSAA) Informatics
    • Research Development 

Research Development Core

Matt Kaeberlein, Director. This Core provides Pilot Study and Junior Faculty Support in the Basic Biology of Aging. This funding allows faculty investigators to rapid pursue new and exciting findings in the study of aging. More information

Program Enrichment Core

Peter Rabinovitch and Matt Kaeberlein, Directors

  • Support for seminars, courses, symposia and workshops
  • Aging Genes/Interventions Database and Shared Resources Database
  • Community outreach and collaboration with other Nathan Shock Centers
  • Statistical consulting for experimental design and analysis  
  • Administrative support

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