Genes (go to Interventions)

A | B | C | D | E | F | G | H | I | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

A
Gene NameOrganismAging Phenotype
aak-2 Caenorhabditis elegans Shortened life-span 
ADA1 Saccharomyces cerevisiae (replicative) Shortened life-span 
age-1 Caenorhabditis elegans Life-span extension 
age-2 Caenorhabditis elegans Life-span extension 
age-n [unknown gene(s)] Caenorhabditis elegans Life-span extension 
aph-1 Caenorhabditis elegans N/A 
ApoE Homo sapiens Correlation 
APP Homo sapiens N/A 
ATM Homo sapiens Shortened life-span 
atp-3 Caenorhabditis elegans Life-span extension 
ATP2 Saccharomyces cerevisiae (replicative) N/A 
ATP2 Saccharomyces cerevisiae (chronological) Shortened life-span 

B
Gene NameOrganismAging Phenotype
B0261.4 Caenorhabditis elegans Life-span extension 
BCY1 Saccharomyces cerevisiae (replicative) Shortened life-span 
beach1 Drosophila melanogaster Shortened life-span 
bec-1 Caenorhabditis elegans Shortened life-span 
BLM Homo sapiens Shortened life-span 
BRE5 Saccharomyces cerevisiae (replicative) Life-span extension 
bsk Drosophila melanogaster Correlation 
BubR1 Mus musculus Shortened life-span 

C
Gene NameOrganismAging Phenotype
C/EBP Mus musculus Life-span extension 
CAT Drosophila melanogaster Life-span extension 
CAT (2) Drosophila melanogaster No effect on life-span 
cco-1 Caenorhabditis elegans Life-span extension 
CCR4 Saccharomyces cerevisiae (replicative) Shortened life-span 
Cct1 Drosophila melanogaster Life-span extension 
CDC25 Saccharomyces cerevisiae (replicative) Life-span extension 
CDC6 Saccharomyces cerevisiae (replicative) Life-span extension 
CDC7 Saccharomyces cerevisiae (replicative) Shortened life-span 
ced-3 Caenorhabditis elegans No effect on life-span 
Ceinsulin-1 Caenorhabditis elegans Life-span extension 
CETP Homo sapiens Correlation 
che-11 Caenorhabditis elegans Life-span extension 
che-13 Caenorhabditis elegans Life-span extension 
che-2 Caenorhabditis elegans Life-span extension 
che-3 Caenorhabditis elegans Life-span extension 
cher Drosophila melanogaster Life-span extension 
chico Drosophila melanogaster Life-span extension 
CIT2 Saccharomyces cerevisiae (replicative) No effect on life-span 
CIT2 _ Saccharomyces cerevisiae (replicative) No effect on life-span 
CKN1 Homo sapiens Shortened life-span 
clk-1 Caenorhabditis elegans Life-span extension 
clk-1 Caenorhabditis elegans Shortened life-span 
clk-2 Caenorhabditis elegans Life-span extension 
clk-3 Caenorhabditis elegans Life-span extension 
COQ3 Saccharomyces cerevisiae (chronological) Shortened life-span 
COX1 Podospora anserina Life-span extension 
COX5 Podospora anserina Life-span extension 
CPR7 Saccharomyces cerevisiae (replicative) No effect on life-span 
CPR7 Saccharomyces cerevisiae (chronological) Life-span extension 
CTF4 Saccharomyces cerevisiae (replicative) Shortened life-span 
ctl-1 Caenorhabditis elegans N/A 
CTT1 Saccharomyces cerevisiae (chronological) Shortened life-span 
CTT1 Saccharomyces cerevisiae (chronological) Life-span extension 
cyc-1 Caenorhabditis elegans Life-span extension 
CYR1 Saccharomyces cerevisiae (chronological) Life-span extension 
CYR1 Saccharomyces cerevisiae (replicative) Life-span extension 
CYT1 Saccharomyces cerevisiae (replicative) No effect on life-span 

D
Gene NameOrganismAging Phenotype
D2030.4 Caenorhabditis elegans Life-span extension 
daf-1 Caenorhabditis elegans No effect on life-span 
daf-10 Caenorhabditis elegans Life-span extension 
daf-12 Caenorhabditis elegans Life-span extension 
daf-15 Caenorhabditis elegans Life-span extension 
daf-16 Caenorhabditis elegans Shortened life-span 
daf-18 Caenorhabditis elegans No effect on life-span 
daf-19 Caenorhabditis elegans Life-span extension 
daf-2 Caenorhabditis elegans Life-span extension 
daf-28 Caenorhabditis elegans Life-span extension 
daf-3 Caenorhabditis elegans No effect on life-span 
daf-4 Caenorhabditis elegans No effect on life-span 
daf-6 Caenorhabditis elegans Life-span extension 
daf-9 Caenorhabditis elegans Life-span extension 
daz-1 Caenorhabditis elegans No effect on life-span 
Dmp53 Drosophila melanogaster Shortened life-span 
Dmp53 Drosophila melanogaster Life-span extension 
DNA2 Saccharomyces cerevisiae (replicative) Shortened life-span 
DNL4 Saccharomyces cerevisiae (replicative) No effect on life-span 
dod-17 Caenorhabditis elegans Life-span extension 
dod-18 Caenorhabditis elegans Life-span extension 
dod-19 Caenorhabditis elegans Life-span extension 
dod-20 Caenorhabditis elegans Life-span extension 
dod-21 Caenorhabditis elegans Life-span extension 
dod-22 Caenorhabditis elegans Life-span extension 
dod-23 Caenorhabditis elegans Life-span extension 
dod-24 Caenorhabditis elegans Life-span extension 
Down Syndrome [unknown gene(s)] Homo sapiens Shortened life-span 
Dp110/p60 Drosophila melanogaster No effect on life-span 
DPOSH Drosophila melanogaster Life-span extension 
Drop-dead Drosophila melanogaster Shortened life-span 
dSIR2 Drosophila melanogaster Life-span extension 
DTS-3 Drosophila melanogaster Life-span extension 

E
Gene NameOrganismAging Phenotype
eat-1 Caenorhabditis elegans Life-span extension 
eat-10 Caenorhabditis elegans No effect on life-span 
eat-13 Caenorhabditis elegans Life-span extension 
eat-18 Caenorhabditis elegans Life-span extension 
eat-2 Caenorhabditis elegans Life-span extension 
eat-3 Caenorhabditis elegans Life-span extension 
eat-5 Caenorhabditis elegans No effect on life-span 
eat-6 Caenorhabditis elegans Life-span extension 
eat-7 Caenorhabditis elegans Shortened life-span 
EcR Drosophila melanogaster Life-span extension 
EF-1 Drosophila melanogaster Life-span extension 
egl-4 Caenorhabditis elegans Life-span extension 

F
Gene NameOrganismAging Phenotype
F13G3.7 Caenorhabditis elegans Life-span extension 
F26E4.6 Caenorhabditis elegans Life-span extension 
F26E4.9 Caenorhabditis elegans Life-span extension 
F28B3.9 Caenorhabditis elegans Life-span extension 
F57B10.3 Caenorhabditis elegans Life-span extension 
Fe65 Homo sapiens N/A 
fem-3 Caenorhabditis elegans No effect on life-span 
fer-15 Caenorhabditis elegans Shortened life-span 
FOB1 Saccharomyces cerevisiae (replicative) Life-span extension 
fog-1 Caenorhabditis elegans No effect on life-span 
fog-2 Caenorhabditis elegans No effect on life-span 
fog-3 Caenorhabditis elegans No effect on life-span 
FPS1S Arabidopsis thaliana N/A 
Fwd Drosophila melanogaster Life-span extension 

G
Gene NameOrganismAging Phenotype
GAL83 Saccharomyces cerevisiae (replicative) No effect on life-span 
gcy-18 Caenorhabditis elegans Life-span extension 
gcy-6 Caenorhabditis elegans Life-span extension 
GH Rattus norvegicus Life-span extension 
GH-1 Homo sapiens Shortened life-span 
GHR Mus musculus Life-span extension 
Ghrhr Mus musculus Life-span extension 
Glial Lazarillo (GLaz) Drosophila melanogaster Life-span extension 
Glial Lazarillo (GLaz) Drosophila melanogaster Shortened life-span 
glp-1 Caenorhabditis elegans Life-span extension 
GPA2 Saccharomyces cerevisiae (replicative) Life-span extension 
GPD1 Saccharomyces cerevisiae (replicative) Shortened life-span 
GPR1 Saccharomyces cerevisiae (replicative) Life-span extension 
Grisea Podospora anserina Life-span extension 
gro-1 Caenorhabditis elegans Life-span extension 

H
Gene NameOrganismAging Phenotype
HAP4 Saccharomyces cerevisiae (replicative) Life-span extension 
HAP5 Saccharomyces cerevisiae (replicative) Shortened life-span 
HDA1 Saccharomyces cerevisiae (replicative) No effect on life-span 
HDF1 Saccharomyces cerevisiae (replicative) Shortened life-span 
HDF2 Saccharomyces cerevisiae (replicative) Shortened life-span 
hep Drosophila melanogaster Life-span extension 
HOG1 Saccharomyces cerevisiae (replicative) Shortened life-span 
HPR5 Saccharomyces cerevisiae (replicative) Shortened life-span 
HSC82 Saccharomyces cerevisiae (replicative) No effect on life-span 
HSC82 Saccharomyces cerevisiae (chronological) No effect on life-span 
hsf-1 Caenorhabditis elegans Shortened life-span 
hsp-16 Caenorhabditis elegans Life-span extension 
hsp-16 Caenorhabditis elegans No effect on life-span 
hsp-6 Caenorhabditis elegans Life-span extension 
HSP104 Saccharomyces cerevisiae (replicative) No effect on life-span 
hsp26 Drosophila melanogaster Life-span extension 
hsp27 Drosophila melanogaster Life-span extension 
hsp68 Drosophila melanogaster Life-span extension 
hTERT Homo sapiens (cell culture) Life-span extension 
Human Sod1 Mus musculus No effect on life-span 
human tau Drosophila melanogaster Shortened life-span 
human thioredoxin Mus musculus Life-span extension 
Hutchinson-Gilford Syndrome [LMNAHomo sapiens Shortened life-span 
HXK2 Saccharomyces cerevisiae (replicative) Life-span extension 

I
Gene NameOrganismAging Phenotype
IDH2 Saccharomyces cerevisiae (replicative) Life-span extension 
IGF-1R Mus musculus Life-span extension 
Indy Drosophila melanogaster Life-span extension 
InR Drosophila melanogaster Life-span extension 
INS Caenorhabditis elegans Life-span extension 
ins-1 Caenorhabditis elegans Life-span extension 
ins-18 Caenorhabditis elegans Life-span extension 
ins-21 Caenorhabditis elegans Life-span extension 
ins-22 Caenorhabditis elegans No effect on life-span 
ins-7 Caenorhabditis elegans Life-span extension 
Insr Mus musculus Life-span extension 
isp-1 Caenorhabditis elegans Life-span extension 

K
Gene NameOrganismAging Phenotype
K01C8.7 Caenorhabditis elegans Life-span extension 
KLOTHO Homo sapiens Correlation 
klotho Mus musculus Shortened life-span 

L
Gene NameOrganismAging Phenotype
LAC1 Saccharomyces cerevisiae (replicative) No effect on life-span 
LAG1 Saccharomyces cerevisiae (replicative) Life-span extension 
LAG2 Saccharomyces cerevisiae (replicative) Life-span extension 
lbp-7 Caenorhabditis elegans Life-span extension 
let-363 Caenorhabditis elegans Life-span extension 
let-363 Caenorhabditis elegans No effect on life-span 
LET-60 Caenorhabditis elegans N/A 
LMNA Homo sapiens Shortened life-span 
LmSIR2 Leishmania infantum Life-span extension 
Longevity-associated locus on chromosome 4 [unknown genes(s)] Homo sapiens Correlation 
lrs-2 Caenorhabditis elegans Life-span extension 

M
Gene NameOrganismAging Phenotype
MATa/alpha Saccharomyces cerevisiae (replicative) Shortened life-span 
mec-1 Caenorhabditis elegans No effect on life-span 
mec-8 Caenorhabditis elegans Life-span extension 
mes-1 Caenorhabditis elegans Life-span extension 
mev-1 Caenorhabditis elegans Shortened life-span 
Mitochondrial aconitase Musca domestica N/A 
Mitochonrdially targeted human catalase Mus musculus Life-span extension 
MORF 4 Homo sapiens N/A 
Mot-2 Homo sapiens (cell culture) Life-span extension 
MPT5 Saccharomyces cerevisiae (replicative) Shortened life-span 
MPT5 Saccharomyces cerevisiae (replicative) Life-span extension 
mrp-5 Caenorhabditis elegans Life-span extension 
MSN2 Saccharomyces cerevisiae (chronological) No effect on life-span 
MSN2 Saccharomyces cerevisiae (replicative) No effect on life-span 
MSN4 Saccharomyces cerevisiae (chronological) No effect on life-span 
MSN4 Saccharomyces cerevisiae (replicative) No effect on life-span 
MsrA Mus musculus Shortened life-span 
MSRA Drosophila melanogaster Life-span extension 
MTH Drosophila melanogaster Life-span extension 
mtl-2 Caenorhabditis elegans Life-span extension 
MTP Homo sapiens Correlation 

N
Gene NameOrganismAging Phenotype
NCA3 Saccharomyces cerevisiae (replicative) Shortened life-span 
nhr-49 Caenorhabditis elegans Shortened life-span 
NMT1 Saccharomyces cerevisiae (replicative) Shortened life-span 
NNT1 Saccharomyces cerevisiae (replicative) Life-span extension 
NPT1 Saccharomyces cerevisiae (replicative) Life-span extension 
NPT1 Saccharomyces cerevisiae (replicative) No effect on life-span 
NPT1 Saccharomyces cerevisiae (replicative) Shortened life-span 
NPY Rattus norvegicus Life-span extension 
NR3C1 Homo sapiens Correlation 
nuc-1 Caenorhabditis elegans Life-span extension 
nuo-2 Caenorhabditis elegans Life-span extension 

O
Gene NameOrganismAging Phenotype
osm-1 Caenorhabditis elegans Life-span extension 
osm-3 Caenorhabditis elegans Life-span extension 
osm-5 Caenorhabditis elegans Life-span extension 
osm-6 Caenorhabditis elegans Life-span extension 
ovo Drosophila melanogaster Life-span extension 

P
Gene NameOrganismAging Phenotype
p66shc Mus musculus Life-span extension 
PARK2 Homo sapiens N/A 
PASG Mus musculus Shortened life-span 
PCMT Drosophila melanogaster Life-span extension 
PDE2 Saccharomyces cerevisiae (replicative) Shortened life-span 
pdk-1 Caenorhabditis elegans Life-span extension 
pen-2 Caenorhabditis elegans N/A 
pep-2 Caenorhabditis elegans Life-span extension 
pes-2 Caenorhabditis elegans Life-span extension 
petite Saccharomyces cerevisiae (replicative) Life-span extension 
pgl-1 Caenorhabditis elegans Life-span extension 
PHB1 Saccharomyces cerevisiae (replicative) Shortened life-span 
PHB2 Saccharomyces cerevisiae (replicative) Shortened life-span 
Pit1 Mus musculus Life-span extension 
PKB Drosophila melanogaster Shortened life-span 
Plau Mus musculus Life-span extension 
PLD alpha Arabidopsis thaliana N/A 
PNC1 Saccharomyces cerevisiae (replicative) Life-span extension 
PNC1 Saccharomyces cerevisiae (replicative) Shortened life-span 
pnk-1 Caenorhabditis elegans Shortened life-span 
POL1 Saccharomyces cerevisiae (replicative) Shortened life-span 
PolgA Mus musculus Shortened life-span 
Prdx1 Mus musculus Shortened life-span 
Prop1 Mus musculus Life-span extension 
PSEN1 Homo sapiens N/A 
PSEN2 Homo sapiens N/A 
puc Drosophila melanogaster Life-span extension 
PUF4 Saccharomyces cerevisiae (replicative) No effect on life-span 

Q
Gene NameOrganismAging Phenotype
QPT1 Saccharomyces cerevisiae (replicative) No effect on life-span 

R
Gene NameOrganismAging Phenotype
rad-8 Caenorhabditis elegans Life-span extension 
RAD1 Saccharomyces cerevisiae (replicative) No effect on life-span 
RAD26 Saccharomyces cerevisiae (replicative) No effect on life-span 
RAD27 Saccharomyces cerevisiae (replicative) Shortened life-span 
RAD51 Saccharomyces cerevisiae (replicative) Shortened life-span 
RAD52 Saccharomyces cerevisiae (replicative) Shortened life-span 
RAD7 Saccharomyces cerevisiae (replicative) No effect on life-span 
RAD9 Saccharomyces cerevisiae (replicative) Shortened life-span 
RAS1 Saccharomyces cerevisiae (replicative) Life-span extension 
RAS1 Saccharomyces cerevisiae (chronological) Shortened life-span 
RAS1 Saccharomyces cerevisiae (replicative) No effect on life-span 
RAS2 Saccharomyces cerevisiae (replicative) Life-span extension 
RAS2 Saccharomyces cerevisiae (chronological) Life-span extension 
RAS2 Saccharomyces cerevisiae (replicative) Shortened life-span 
Rdh Drosophila melanogaster Life-span extension 
REI1 Saccharomyces cerevisiae (replicative) Life-span extension 
rgn Mus musculus Shortened life-span 
RIF1 Saccharomyces cerevisiae (replicative) Shortened life-span 
ROM2 Saccharomyces cerevisiae (replicative) Life-span extension 
RPD3 Saccharomyces cerevisiae (replicative) Life-span extension 
RPD3 Drosophila melanogaster Life-span extension 
RPL31A Saccharomyces cerevisiae (replicative) Life-span extension 
RPL6B Saccharomyces cerevisiae (replicative) Life-span extension 
RSR1 Saccharomyces cerevisiae (replicative) Shortened life-span 
RTG2 Saccharomyces cerevisiae (replicative) Shortened life-span 
RTG3 Saccharomyces cerevisiae (replicative) Life-span extension 

S
Gene NameOrganismAging Phenotype
SAG101 Arabidopsis thaliana N/A 
SAG12 Arabidopsis thaliana N/A 
SCH9 Saccharomyces cerevisiae (chronological) Life-span extension 
SCH9 Saccharomyces cerevisiae (replicative) Life-span extension 
scl-1 Caenorhabditis elegans Shortened life-span 
SCP1 Saccharomyces cerevisiae (replicative) Life-span extension 
sgk-1 Caenorhabditis elegans Life-span extension 
SGS1 Saccharomyces cerevisiae (replicative) Shortened life-span 
SIM1 Saccharomyces cerevisiae (replicative) Shortened life-span 
sip-1 Caenorhabditis elegans No effect on life-span 
SIP1 Saccharomyces cerevisiae (replicative) Shortened life-span 
SIP2 Saccharomyces cerevisiae (replicative) Shortened life-span 
sir-2.1 Caenorhabditis elegans Life-span extension 
SIR2 Saccharomyces cerevisiae (replicative) Life-span extension 
SIR2 Saccharomyces cerevisiae (replicative) Shortened life-span 
SIR3 Saccharomyces cerevisiae (replicative) Shortened life-span 
SIR3 Saccharomyces cerevisiae (replicative) No effect on life-span 
SIR4 Saccharomyces cerevisiae (replicative) Shortened life-span 
SIR4 Saccharomyces cerevisiae (replicative) Life-span extension 
SIRT1 Mus musculus (cell culture) Life-span extension 
SIRT3 Homo sapiens Correlation 
SLT2 Saccharomyces cerevisiae (replicative) No effect on life-span 
SNCA Homo sapiens N/A 
SNF1 Saccharomyces cerevisiae (replicative) Shortened life-span 
SNF4 Saccharomyces cerevisiae (replicative) Life-span extension 
SOD1 Drosophila melanogaster Life-span extension 
SOD1 Saccharomyces cerevisiae (chronological) Shortened life-span 
SOD1 Saccharomyces cerevisiae (replicative) No effect on life-span 
SOD1 Saccharomyces cerevisiae (replicative) Shortened life-span 
SOD1 Saccharomyces cerevisiae (chronological) Life-span extension 
SOD2 Drosophila melanogaster Life-span extension 
SOD2 Saccharomyces cerevisiae (chronological) Shortened life-span 
Sod2 Mus musculus Shortened life-span 
SOD2 Saccharomyces cerevisiae (chronological) Life-span extension 
SOD2 Saccharomyces cerevisiae (replicative) Shortened life-span 
spe-10 Caenorhabditis elegans Life-span extension 
spe-26 Caenorhabditis elegans Life-span extension 
SSD1 Saccharomyces cerevisiae (replicative) Life-span extension 
STE12 Saccharomyces cerevisiae (replicative) No effect on life-span 
STE4 Saccharomyces cerevisiae (replicative) No effect on life-span 
Strain HG246 [unknown gene(s)] Caenorhabditis elegans Life-span extension 
Strain HG25 [unknown gene(s)] Caenorhabditis elegans Life-span extension 
Strain HG96 [unknown gene(s)] Caenorhabditis elegans Life-span extension 
Sug Drosophila melanogaster Life-span extension 
SUN4 Saccharomyces cerevisiae (replicative) Shortened life-span 
SWI4 Saccharomyces cerevisiae (replicative) Shortened life-span 

T
Gene NameOrganismAging Phenotype
T02H6.11 Caenorhabditis elegans Life-span extension 
T06D8.6 Caenorhabditis elegans Life-span extension 
tau Mesocricetus auratus Life-span extension 
tax-2 Caenorhabditis elegans No effect on life-span 
tax-4 Caenorhabditis elegans Life-span extension 
Terc Mus musculus Shortened life-span 
Test Gene Homo sapiens Life-span extension 
tkr-1 Caenorhabditis elegans Life-span extension 
TLC1 Saccharomyces cerevisiae (replicative) Life-span extension 
top3b Mus musculus Shortened life-span 
TOR1 Saccharomyces cerevisiae (replicative) Life-span extension 
TPK2 Saccharomyces cerevisiae (replicative) Life-span extension 
TPS2 Saccharomyces cerevisiae (replicative) No effect on life-span 
TRp53 Mus musculus Shortened life-span 
TRp63 Mus musculus Shortened life-span 
tub-1 Caenorhabditis elegans Life-span extension 

U
Gene NameOrganismAging Phenotype
UCHL1 Homo sapiens N/A 
UCP3 Mus musculus Correlation 
unc-1 Caenorhabditis elegans No effect on life-span 
unc-13 Caenorhabditis elegans Life-span extension 
unc-15 Caenorhabditis elegans No effect on life-span 
unc-2 Caenorhabditis elegans No effect on life-span 
unc-20 Caenorhabditis elegans No effect on life-span 
unc-24 Caenorhabditis elegans No effect on life-span 
unc-25 Caenorhabditis elegans No effect on life-span 
unc-26 Caenorhabditis elegans Life-span extension 
unc-29 Caenorhabditis elegans No effect on life-span 
unc-30 Caenorhabditis elegans No effect on life-span 
unc-31 Caenorhabditis elegans Life-span extension 
unc-32 Caenorhabditis elegans Life-span extension 
unc-35 Caenorhabditis elegans No effect on life-span 
unc-4 Caenorhabditis elegans Life-span extension 
unc-46 Caenorhabditis elegans No effect on life-span 
unc-47 Caenorhabditis elegans No effect on life-span 
unc-49 Caenorhabditis elegans No effect on life-span 
unc-54 Caenorhabditis elegans No effect on life-span 
unc-6 Caenorhabditis elegans No effect on life-span 
unc-64 Caenorhabditis elegans Life-span extension 
unc-7 Caenorhabditis elegans No effect on life-span 
unc-76 Caenorhabditis elegans Life-span extension 
unc-78 Caenorhabditis elegans No effect on life-span 
unc-79 Caenorhabditis elegans No effect on life-span 
unc-80 Caenorhabditis elegans No effect on life-span 
URE2 Saccharomyces cerevisiae (replicative) Life-span extension 
UTH1 Saccharomyces cerevisiae (replicative) Life-span extension 
UTH3 Saccharomyces cerevisiae (replicative) Life-span extension 

V
Gene NameOrganismAging Phenotype
VhaSFD Drosophila melanogaster Life-span extension 
vit-1 Caenorhabditis elegans No effect on life-span 
vit-2 Caenorhabditis elegans Life-span extension 
vit-5 Caenorhabditis elegans Life-span extension 

W
Gene NameOrganismAging Phenotype
W09C5.8 Caenorhabditis elegans Life-span extension 
WRKY6 Arabidopsis thaliana N/A 
WRN Homo sapiens Shortened life-span 

X
Gene NameOrganismAging Phenotype
XPD Mus musculus Shortened life-span 

Y
Gene NameOrganismAging Phenotype
YBR238C Saccharomyces cerevisiae (replicative) Life-span extension 
YBR255W Saccharomyces cerevisiae (replicative) Life-span extension 
YBR266C Saccharomyces cerevisiae (replicative) Life-span extension 
YGL014W Saccharomyces cerevisiae (replicative) No effect on life-span 
YOR135C Saccharomyces cerevisiae (replicative) Life-span extension 

Z
Gene NameOrganismAging Phenotype
ZDS1 Saccharomyces cerevisiae (replicative) Life-span extension 
ZDS2 Saccharomyces cerevisiae (replicative) Shortened life-span 

Interventions (go to Genes)

A | B | C | D | E | F | G | H | K | L | M | N | O | P | R | S | T | U | V

*
Intervention NameOrganismAging Phenotype
(R)-N-(2-heptyl)-N-methylpropargylamine Drosophila melanogaster No effect on life-span 
2-mercaptoethanol Mus musculus Life-span extension 
2-mercaptoethylamine hydrochloride Mus musculus Life-span extension 
60% Oxygen Rattus norvegicus Shortened life-span 

A
Intervention NameOrganismAging Phenotype
Ablation of dilp2 producing neurosecretory cells Drosophila melanogaster Life-span extension 
Accelerated photoperiodic cycle Microcebus murinus Shortened life-span 
Acetyl-L-Carnitine Rattus norvegicus N/A 
alpha-phenyl-N-t-butyl-nitrone Homo sapiens (cell culture) Life-span extension 
alpha-phenyl-N-t-butyl-nitrone Mus musculus Life-span extension 
alpha-phenyl-N-t-butyl-nitrone Musca domestica Shortened life-span 
Antimycin A Caenorhabditis elegans Life-span extension 
Antimycin A Saccharomyces cerevisiae (chronological) Shortened life-span 
antioxidant drug EUK-134 Musca domestica Shortened life-span 
antioxidant drug EUK-134 Caenorhabditis elegans Life-span extension 
antioxidant drug EUK-8 Musca domestica Shortened life-span 
antioxidant drug EUK-8 Caenorhabditis elegans Shortened life-span 
antioxidant drug EUK-8 Caenorhabditis elegans Life-span extension 
Antioxidant treatment Rattus norvegicus No effect on life-span 
Axenic growth Caenorhabditis elegans Life-span extension 

B
Intervention NameOrganismAging Phenotype
Butein Saccharomyces cerevisiae (replicative) Life-span extension 
Butylated hydroxy anisole Zaprionus paravittiger Life-span extension 
Butylated hydroxytoluene Drosophila bipectinata Life-span extension 

C
Intervention NameOrganismAging Phenotype
Caloric restriction Macaca mulatta N/A 
Caloric restriction Rattus norvegicus Life-span extension 
Caloric restriction Saccharomyces cerevisiae (replicative) Life-span extension 
Caloric restriction Caenorhabditis elegans Life-span extension 
Caloric restriction Drosophila melanogaster Life-span extension 
Caloric restriction Frontinella pyramitela Life-span extension 
Caloric restriction Canis lupus familiaris Life-span extension 
Caloric restriction Ceratitis capitata No effect on life-span 
Caloric restriction Asplanchna brightwelli Life-span extension 
Caloric restriction Lebistes reticulatus Life-span extension 
Caloric restriction Daphnia pulex Life-span extension 
Caloric restriction Brachionus calyciflorus Life-span extension 
Caloric restriction Asplanchna girodi Life-span extension 
Caloric restriction Brachionus patulus Life-span extension 
Caloric restriction Brachionus plicatilis Shortened life-span 
Caloric restriction Euclanis dilatata Life-span extension 
Caloric restriction Encentrum linnhei Life-span extension 
Caloric restriction Keratella testudo Shortened life-span 
Caloric restriction Philodina acuticornis Life-span extension 
Caloric restriction Synchaeta pectinata Shortened life-span 
Caloric restriction Tokophrya infusionum Life-span extension 
Caloric restriction Homo sapiens N/A 
Caloric restriction Mus musculus Life-span extension 
CDTA Drosophila melanogaster Life-span extension 
Cold stress Haematobia irritans Life-span extension 
Continuous dark Asplanchna brightwelli Life-span extension 
Copper gluconate Mus musculus Shortened life-span 
Cortisone Asplanchna brightwelli Life-span extension 
Curare Asplanchna brightwelli Life-span extension 

D
Intervention NameOrganismAging Phenotype
D-glucosamine Saccharomyces cerevisiae (replicative) No effect on life-span 
D-Glucose Saccharomyces cerevisiae (replicative) Life-span extension 
D-Glycerol Saccharomyces cerevisiae (replicative) Life-span extension 
D-sorbitol Saccharomyces cerevisiae (replicative) Life-span extension 
D-Xylitol Saccharomyces cerevisiae (replicative) Life-span extension 
Decreased oxygen concentration Homo sapiens (cell culture) Life-span extension 
Decreased temperature Asplanchna brightwelli Life-span extension 
deprenyl Rattus norvegicus Life-span extension 
deprenyl Mesocricetus auratus Life-span extension 
deprenyl Canis lupus familiaris Life-span extension 
deprenyl Mus musculus Life-span extension 
deprenyl Drosophila melanogaster No effect on life-span 
deprenyl Rattus norvegicus Shortened life-span 
Dietary cadmium Drosophila melanogaster Shortened life-span 
Dietary iron Drosophila melanogaster Correlation 
Dietary restriction of coenzyme Q Caenorhabditis elegans Life-span extension 
Dietary restriction of coenzyme Q Drosophila melanogaster Shortened life-span 
Diiodomethane Drosophila melanogaster Life-span extension 
Diphenylhydantoin Mus musculus Life-span extension 
DNA and RNA Injection Rattus norvegicus Life-span extension 

E
Intervention NameOrganismAging Phenotype
Ectopic extrachromosomal rDNA circle (ERC) induction. Saccharomyces cerevisiae (replicative) Shortened life-span 
EDTA Mytilina brevispina var redunca Life-span extension 
EGb 761 Caenorhabditis elegans Life-span extension 
EGTA Mytilina brevispina var redunca Life-span extension 
Epithalamin Drosophila melanogaster Life-span extension 
Ethoxyquin Mus musculus Life-span extension 
Exercise Mus musculus No effect on life-span 
Exercise Rattus norvegicus Life-span extension 

F
Intervention NameOrganismAging Phenotype
FCCP Saccharomyces cerevisiae (chronological) Life-span extension 
Fisetin Saccharomyces cerevisiae (replicative) Life-span extension 
Fish oil Mus musculus Life-span extension 

G
Intervention NameOrganismAging Phenotype
Galactose feeding Drosophila melanogaster Shortened life-span 
germ line ablation Caenorhabditis elegans Life-span extension 
germ line ablation Pristionchus pacificus Life-span extension 
Growth on carbenicillin treated bacteria Caenorhabditis elegans Life-span extension 
Growth on kanamycin treated bacteria Caenorhabditis elegans Life-span extension 
Growth on UV-killed bacteria Caenorhabditis elegans Life-span extension 

H
Intervention NameOrganismAging Phenotype
Heat Shock Saccharomyces cerevisiae (replicative) Life-span extension 
Heat Shock Caenorhabditis elegans Life-span extension 
Heat Shock Drosophila melanogaster Life-span extension 
Hibernation Mesocricetus brandti Life-span extension 
High Osmolarity Saccharomyces cerevisiae (replicative) Life-span extension 
Human Growth Hormone Therapy Rattus norvegicus No effect on life-span 
Human Growth Hormone Therapy Homo sapiens N/A 
Human Growth Hormone Therapy Mus musculus No effect on life-span 
Hypergravity Drosophila melanogaster Life-span extension 

K
Intervention NameOrganismAging Phenotype
Kinetin dietary supplementation Zaprionus paravittiger Life-span extension 

L
Intervention NameOrganismAging Phenotype
L- carnosine Homo sapiens (cell culture) Life-span extension 

M
Intervention NameOrganismAging Phenotype
Magnesium thiazolidine-4-carboxylic acid Aedes aegypti Life-span extension 
Melatonin Mus musculus Life-span extension 
Melatonin Drosophila melanogaster No effect on life-span 
Melatonin Drosophila melanogaster Life-span extension 
Methionine Mus musculus Shortened life-span 
Methionine Zaprionus paravittiger Life-span extension 
Methionine restriction Rattus norvegicus Life-span extension 
Methionine restriction Mus musculus Life-span extension 
Modified Mediterranean diet Homo sapiens Correlation 

N
Intervention NameOrganismAging Phenotype
N,N'-diphenyl-1,4-diphenylenediamine Caenorhabditis elegans No effect on life-span 
N-acetylcysteine Drosophila melanogaster Life-span extension 
N-benzyl hydroxylamine Homo sapiens (cell culture) Life-span extension 
N-methyl hydroxylamine Homo sapiens (cell culture) Life-span extension 
N-t-butyl hydroxylamine Homo sapiens (cell culture) Life-span extension 
Nicotinamide Homo sapiens (cell culture) No effect on life-span 
Nicotinamide Saccharomyces cerevisiae (replicative) Shortened life-span 
Nicotinic Acid Saccharomyces cerevisiae (replicative) No effect on life-span 
Nordihydroguaiaretic acid Aedes aegypti Life-span extension 

O
Intervention NameOrganismAging Phenotype
ovary transplantation Mus musculus Life-span extension 
Oxygen pretreatment Caenorhabditis elegans Life-span extension 

P
Intervention NameOrganismAging Phenotype
Paraquat Saccharomyces cerevisiae (chronological) Shortened life-span 
PBA Drosophila melanogaster Life-span extension 
Phenformin Mus musculus Life-span extension 
Prevention of flight Musca domestica Life-span extension 
Prevention of mating (by removal of females) Drosophila melanogaster Life-span extension 
Propyl gallate Zaprionus paravittiger Life-span extension 

R
Intervention NameOrganismAging Phenotype
R-Alpha-Lipoic Acid Rattus norvegicus N/A 
Repeated Mild Heat Shock Homo sapiens (cell culture) No effect on life-span 
Resveratrol Saccharomyces cerevisiae (replicative) Life-span extension 
Resveratrol Saccharomyces cerevisiae (chronological) No effect on life-span 
Resveratrol Caenorhabditis elegans Life-span extension 
Resveratrol Drosophila melanogaster Life-span extension 
Resveratrol Saccharomyces cerevisiae (replicative) No effect on life-span 
Retinoic acid Homo sapiens (cell culture) Life-span extension 
Royal Jelly Mus musculus Life-span extension 

S
Intervention NameOrganismAging Phenotype
Sodium borate Drosophila melanogaster Life-span extension 
Sodium citrate Mytilina brevispina var redunca Life-span extension 
Sodium cyanide Saccharomyces cerevisiae (chronological) Life-span extension 
Sodium hypophosphite Zaprionus paravittiger Life-span extension 
Sodium selenite Zaprionus paravittiger Life-span extension 
sodium tartrate Mytilina brevispina var redunca Life-span extension 

T
Intervention NameOrganismAging Phenotype
Tamarixetin Caenorhabditis elegans Life-span extension 
Tea extract Drosophila melanogaster Life-span extension 
Telomere length Saccharomyces cerevisiae (replicative) N/A 
Thyroxine Rattus norvegicus Life-span extension 
Tryptophan Restriction Mus musculus Life-span extension 
Tryptophan Restriction Rattus norvegicus Life-span extension 

U
Intervention NameOrganismAging Phenotype
UV radiation Asplanchna brightwelli Shortened life-span 

V
Intervention NameOrganismAging Phenotype
Vitamin C Caenorhabditis elegans No effect on life-span 
Vitamin C Homo sapiens (cell culture) Life-span extension 
Vitamin E Asplanchna brightwelli Life-span extension 
Vitamin E Zaprionus paravittiger Life-span extension 
Vitamin E Philodina acuticornis Life-span extension 
Vitamin E Mus musculus No effect on life-span 
Vitamin E Caenorhabditis elegans No effect on life-span 
Vitamin E Caenorhabditis elegans Life-span extension