OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion of NPT1 shortens life span in W303R. NPT1 is required for life span extension by caloric restriction (Lin et al., 2000).
Gene FunctionNicotinate phosphoribosyltransferase. Involved in NAD biosynthesis.
Other PhenotypesMutation of NPT1 results in a loss of telomere and rDNA silencing (Smith et al., 2000). This effect is likely caused by a loss of SIR2 activity due to decreased cellular NAD levels. Mutation of NPT1 is synthetically lethal with mutation of QPT1 (Lin et al., 2000).
HomologsS.p. Spac1486.06
C.e. Y94H6A.148.P
Primary ReferenceS. J. Lin, P. A. Defossez, L. Guarente, Requirement of NAD and Lin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8.
Other ReferencesSmith, J. S., Brachmann, C. B., Celic, I., Kenna, M. A., Muhammad, S., Starai, V. J., Avalos, J. L., Escalante-Semerena, J. C., Grubmeyer, C., Wolberger, C., and Boeke, J. D. (2000). A phylogenetically conserved NAD+-dependent protein deacetylase activity
Relevant LinksYPD:
Keywordscaloric restriction, metabolism, replicative senescence, Saccharomyces, cerevisiae, yeast