OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeRecessive
Descriptionnmt1-451D allele shortens life span by 50% at 24°C (permissive temperature) (Ashrafi et al., 2000)
Gene FunctionN-myristoyltransferase (Duronio et al., 1990)
Other PhenotypesNull mutant is lethal. Decreased resistance to acute and gradual nutrient deprivation, even at permissive temperature (Ashrafi et al., 1998).
HomologsS.p. Spbc2g2.11
D.m. NMT
M.m. NMT1, NMT2
H.s. NMT1, NMT2
Primary ReferenceAshrafi, K., Lin, S. S., Manchester, J. K., and Gordon, J. I. (2000). Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14, 1872-85. [Abstract]
Other ReferencesDuronio, R. J., Jackson-Machelski, E., Heuckeroth, R. O., Olins, P. O., Devine, C. S., Yonemoto, W., Slice, L. W., Taylor, S. S., and Gordon, J. I. (1990). Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification i [Abstract]
Ashrafi, K., Farazi, T. A., and Gordon, J. I. (1998). A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase. J Biol Chem 273, 25864-74. [Abstract]
Relevant LinksSGD:
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae