OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDisruption shortens mean (87.5% of normal), but not maximum, lifespan without causing any other gross changes in cell cycle parameters or growth characteristics. (Austriaco, 1996a).
Gene FunctionNCA3 is involved in mitochondrial mRNA processing/modification. (Pelissier et al., 1995; Pelissier et al., 1992).
Other PhenotypesIn combination with an NCA2 disruption, NCA3 disruption causes a cryosensitive phenotype on non-fermentable carbon sources due to a defect in the F1-F0 ATP synthase due to misbalancing of alternate spliceforms of mitochondrial mRNA encoding subunits 6 and 8 of the synthase. (Pelissier et al., 1995)
HomologsS.c. SUN4, UTH1, SIM1
S.p. Spbc2G2.17c, psu1, Spcc74.07c
Primary ReferenceAustriaco, N. R., Jr. (1996a). UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae. In Biology (Cambridge: Massachusetts Institute of Technology).
Other ReferencesAustriaco, N. R., Jr. (1996b). Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. Yeast 12, 623-30. [Abstract]
Pelissier, P., Camougrand, N., Velours, G., and Guerin, M. (1995). NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae. Curr Genet 27, 409-16. [Abstract]
Pelissier, P. P., Camougrand, N. M., Manon, S. T., Velours, G. M., and Guerin, M. G. (1992). Regulation by nuclear genes of the mitochondrial synthesis of subunits 6 and 8 of the ATP synthase of Saccharomyces cerevisiae. J Biol Chem 267, 2467-73. [Abstract]
Relevant LinksSGD:
Keywordsmitochondria, yeast, replicative senescence, Saccharomyces, cerevisiae, RNA