OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionDisruption causes 35% extension in life span (Lin et al., 1998).
Gene FunctionUnknown. Member of the 7-TM protein superfamily.
Other PhenotypesDisruption causes increased resistance to stressors, including dietary paraquat, starvation, and high temperature. (Lin et al., 1998)
HomologsM.m. EMR-1
R.r. LR
H.s. CD97
Primary ReferenceLin, Y. J., Seroude, L., and Benzer, S. (1998). Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282, 943-6. [Abstract]
Other ReferencesNone.
Relevant LinksFlyBase:
KeywordsDrosophila, fly, D. melanogaster, oxidative stress, heat shock, caloric restriction, metabolism