NameMTH
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
Strainunknown
DescriptionDisruption causes 35% extension in life span (Lin et al., 1998).
Gene FunctionUnknown. Member of the 7-TM protein superfamily.
Other PhenotypesDisruption causes increased resistance to stressors, including dietary paraquat, starvation, and high temperature. (Lin et al., 1998)
HomologsM.m. EMR-1
R.r. LR
H.s. CD97
Primary ReferenceLin, Y. J., Seroude, L., and Benzer, S. (1998). Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282, 943-6. [Abstract]
Other ReferencesNone.
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0023000
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=38058
KeywordsDrosophila, fly, D. melanogaster, oxidative stress, heat shock, caloric restriction, metabolism