OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
Descriptionmsn2­ msn4­ has no effect on lifespan (Lin et al., 2000)
Gene FunctionTranscriptional activator that mediates stress-induced gene expression; repressed by cAMP-PKA pathway (Smith et al., 1998)
Other Phenotypesnone
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesSmith, A., Ward, M. P., and Garrett, S. (1998). Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. Embo J 17, 3556-64. [Abstract]
Relevant LinksSGD:
Keywordsoxidative stress, heat shock, signaling, transcription factor, yeast, replicative senescence, Saccharomyces, cerevisiae