NameMORF 4
OrganismHomo sapiens
Aging PhenotypeN/A
Allele TypeOverexpression
StrainHeLa cell lines and others
DescriptionThe mortality factor4 (MORF 4) gene reverses the immortal phenotype of immortal cell lines in complementation group B (Bertram et al, 1999). The MORF 4 gene was identified by analysis of microcell fusions that rescue the immortal phenotype.
Gene FunctionThe protein has a leucine zipper motif and is localized in the nucleus (Bertram et al, 1999).
Other PhenotypesCellular senescence is dominant over immortality in fused hybrids of normal and immortal human cells in culture (Pereira-Smith and Smith, 1983). Fusion of immortal cell lines with each other led to the identification of four complementation groups for immortality (Pereira-Smith and Smith, 1988).
HomologsS.c. EAF3
S.p. alp13
C.e. CE-1
D.m. MRG15
M.m. SID393, MSL3L1
H.s. MRG15, MSL3L1
Primary ReferenceBertram, M. J., Berube, N. G., Hang-Swanson, X., Ran, Q., Leung, J. K., Bryce, S., Spurgers, K., Bick, R. J., Baldini, A., Ning, Y., Clark, L. J., Parkinson, E. K., Barrett, J. C., Smith, J. R., and Pereira-Smith, O. M. (1999). Identification of a gene th [Abstract]
Other ReferencesPereira-Smith, O. M., and Smith, J. R. (1983). Evidence for the recessive nature of cellular immortality. Science 221, 964-6. [Abstract]
Pereira-Smith OM, Smith JR. 1988. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc Natl Acad Sci U S A. 85:6042-6. [Abstract]
Relevant LinksLocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=10934
Keywordshuman, replicative senescence, homo sapiens, mortality factor 4