InterventionCaloric restriction
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainNZB X NZW and multiple other strains
DescriptionCaloric restriction increases life span in mice. Caloric restriction begun at 6 weeks has a greater effect than if begun at 12 weeks (Weindruch et al., 1979; Kubo et al, 1984).
The gene expression profile of aging mice is retarded by caloric restriction (Lee at al, 1999).
Gene FunctionN/A
Other PhenotypesCaloric restriction inhibits the development of lymphoproliferative disease, delays development of glomerulonephritis and maintains immunologic responses.
Primary ReferenceWeindruch, R. H., Kristie, J. A., Cheney, K. E., and Walford, R. L. (1979). Influence of controlled dietary restriction on immunologic function and aging, Fed Proc 38, 2007-16. [Abstract]
Kubo, C., Day, N. K., and Good, R. A. (1984). Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice. Proc Natl Acad Sci U S A 81, 5831-5. [Abstract]
Other ReferencesLee CK, Klopp RG, Weindruch R, Prolla TA. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science. 285:1390-3 [Abstract]
Relevant LinksNone
KeywordsMus, musculus, mouse, caloric restriction, metabolism, dietary restriction, calorie restriction