InterventionCaloric restriction
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainNZB X NZW and multiple other strains
DescriptionCaloric restriction increases life span in mice. Caloric restriction begun at 6 weeks has a greater effect than if begun at 12 weeks (Weindruch et al., 1979; Kubo et al, 1984).
The gene expression profile of aging mice is retarded by caloric restriction (Lee at al, 1999).
Gene FunctionN/A
Other PhenotypesCaloric restriction inhibits the development of lymphoproliferative disease, delays development of glomerulonephritis and maintains immunologic responses.
HomologsN/A
Primary ReferenceWeindruch, R. H., Kristie, J. A., Cheney, K. E., and Walford, R. L. (1979). Influence of controlled dietary restriction on immunologic function and aging, Fed Proc 38, 2007-16. [Abstract]
Kubo, C., Day, N. K., and Good, R. A. (1984). Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice. Proc Natl Acad Sci U S A 81, 5831-5. [Abstract]
Other ReferencesLee CK, Klopp RG, Weindruch R, Prolla TA. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science. 285:1390-3 [Abstract]
Relevant LinksNone
KeywordsMus, musculus, mouse, caloric restriction, metabolism, dietary restriction, calorie restriction