NameMitochondrial aconitase
OrganismMusca domestica
Aging PhenotypeN/A
Allele TypeN/A
DescriptionAconitase is a specific target of oxidative modification during aging of the housefly, M. domestica (Yan et al., 1997).
Gene FunctionAconitase catalyzed the interconversion of citrate and isocitrate in the citric acid cycle.
Other PhenotypesOxidative modification reversibly inactivates aconitase, a 4Fe-4S cluster-containing enzyme (Longo et al., 1999; Yan et al., 1997).
Primary ReferenceYan, L. J., Levine, R. L., and Sohal, R. S. (1997). Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A 94, 11168-72. [Abstract]
Other ReferencesLongo, V. D., Liou, L. L., Valentine, J. S., and Gralla, E. B. (1999). Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365, 131-42. [Abstract]
Relevant LinksN/A
KeywordsMusca domestica, housefly, metabolism, oxidative stress, mitochondria