OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function shortens life span to 66% of wild type and accelerates accumulation of aging-associated biomarkers such as protein carbonyls and fluorescent materials (Ishii et al., 1998).
Gene FunctionSuccinate dehydrogenase cytochrome b.
Other PhenotypesMutants are sensitive to paraquat, slow growing, and demonstrate low fecundity. Mutants show a 50% reduction in superoxide dismutase activity relative to wild type (Ishii et al., 1990).
HomologsS.c. YMR118, SDH3
S.p. Spcc330.12c
D.m. CG6666, CG6629
Primary ReferenceIshii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., and Suzuki, K. (1998). A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature 394, 694-7. [Abstract]
Other ReferencesIshii, N., Takahashi, K., Tomita, S., Keino, T., Honda, S., Yoshino, K., and Suzuki, K. (1990). A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. Mutat Res 237, 165-71. [Abstract]
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., and Lithgow, G. J. (2000). Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-9. [Abstract]
Relevant LinksWormBase:
Keywordsmetabolism, oxidative stress, DNA damage, Caenorhabditis, elegans, worm