OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionRecessive loss of function allele extends life span (Apfeld and Kenyon, 1999).
Gene FunctionRNA-binding protein splicing factor. Regulates alternative splicing of unc-52 (Lundquist et al., 1996). Mechanosensory defective
Other PhenotypesMechanosensory defective. Defective dye filling of sensory neurons (Lundquist and Herman, 1994)
HomologsS.c. WHI3, WHI4, NAM8
S.p. Spcc16c4.07, mde7
C.e. etr-1
D.m. CPO, CG18435, SNF, CstF-64
M.m. LOC56328, SNRPA
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesLundquist, E. A., and Herman, R. K. (1994). The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2. Genetics 138, 83-101. [Abstract]
Lundquist, E. A., Herman, R. K., Rogalski, T. M., Mullen, G. P., Moerman, D. G., and Shaw, J. E. (1996). The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts. Development 1 [Abstract]
Relevant LinksWormPD:
Keywordsneurons, Caenorhabditis, elegans, worm