OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeN/A
DescriptionMating type heterozygosity results in an approximately 20% reduction in mean life span. This effect occurs in both haploid and diploid cells and is likely due to increased homologous recombination and rDNA circle formation (Kaeberlein et al., 1999)
Gene FunctionN/A
Other PhenotypesMating-type heterozygosity results in increased homologous recombination (Heude and Fabre, 1993).
Primary ReferenceKaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Other ReferencesHeude, M., and Fabre, F. (1993). a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects. Genetics 133, 489-98. [Abstract]
Relevant LinksN/A
KeywordsrDNA, recombination, DNA repair, yeast, replicative senescence, Saccharomyces cerevisiae, sterility, silencing, signaling, homologous recombination