NameLAG2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainSP1
DescriptionOverexpression increases life span by approximately 20% (Childress et al., 1996). Overexpression induced at generation 12 similarly increases lifespan. Deletion shortens life span by approximately 50%. (Childress et al., 1996).
Gene FunctionUnknown.
Other PhenotypesLAG2 transcript is preferentially expressed in young cells (Childress et al., 1996).
HomologsNone.
Primary ReferenceChildress, A. M., Franklin, D. S., Pinswasdi, C., and Kale, S. (1996). LAG2, a gene that determines yeast longevity. Microbiology 142, 2289-97. [Abstract]
Other ReferencesNone.
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=LAG2
YPD:http://www.proteome.com/databases/YPD/reports/LAG2.html
Keywordsyeast, replicative senescence, Saccharomyces cerevisiae