OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionDeletion increases lifespan in strain YPHDF-1A by approximately 50% (D’mello et al., 1994) Deletion has no significant effect on lifespan in strains W303R or PSY316 (N. Bishop, G. Liszt, and L. Guarente, unpublished).
Gene FunctionUnknown. Tomato plant homolog thought to be involved in ceramide synthesis (Brandwagt, 2000).
Other PhenotypesLAG1 transcript is preferentially expressed in young cells (D’mello et al., 1994).
Null mutant is viable and has no obvious phenotype but shows delayed ER to Golgi transport when combined with a mutation in DGT1 (Barz and Walter, 1999).
Null mutant is synthetically lethal with deletion of lac1 .
HomologsS.c. LAC1
C.e. LAG1-1, LAG1-2
H.s. LAG1
Primary ReferenceD'Mello N, P., Childress, A. M., Franklin, D. S., Kale, S. P., Pinswasdi, C., and Jazwinski, S. M. (1994). Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem 269, 15451-9. [Abstract]
Other ReferencesBarz, W. P., and Walter, P. (1999). Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to- Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell 10, 1043-59. [Abstract]
Brandwagt, B. F., Mesbah, L. A., Takken, F. L., Laurent, P. L., Kneppers, T. J., Hille, J., and Nijkamp, H. J. (2000). A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Pro [Abstract]
Relevant LinksYPD:
Keywordsyeast, replicative senescence, Saccharomyces cerevisiae, ceramides