NameLAC1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainPSY316, W303R
DescriptionHomolog of LAG1(Jiang et al., 1998). Deletion has no effect on lifespan in strains W303R and PSY316 (N. Bishop, G. Liszt, and L. Guarente, unpublished).
Gene FunctionUnknown.
Other PhenotypesNull mutant has no obvious growth defect (Barz and Walter, 1999). Mutation of LAG1 is synthetically lethal with mutation of LAC1 (Jiang et al., 1998)
HomologsS.c. LAG1
C.e. LAG1-1, LAG1-2
H.s. LAG1
Primary ReferenceJiang, J. C., Kirchman, P. A., Zagulski, M., Hunt, J., and Jazwinski, S. M. (1998). Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res 8, 1259-72. [Abstract]
Other ReferencesBarz, W. P., and Walter, P. (1999). Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to- Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell 10, 1043-59. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=lac1
YPD: http://www.proteome.com/databases/YPD/reports/lac1.html
Keywordsyeast, replicative senescence, Saccharomyces cerevisiae