OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainC57BL/6J and C3H/J mixture; same phenotype in BALB/c (after repeated backcrossing)
Descriptionkl/kl mice initially develop normally but show growth retardation starting at 3-4 weeks of age. Their average lifespan is 61 days (none more than 100 days). The mice gradually become inactive, with reduced stride length, atrophic genital organs, atrophy of the thymus, arteriosclerosis (medial calcification and intimal thickening), ectopic calcification in arterial walls, osteoporosis, skin atrophy, impaired maturation of gonadal cells, emphysema, reduced growth hormone-producing cells in the pituitary gland, slight hypercalcemia, and hyperphosphatemia (Kuro-o et al, 1997). This syndrome is said to resemble human aging.
Gene FunctionThe klotho gene has homology to beta-glucosidases (Kuro-o et al, 1997). It is highly expressed in brain and kidney (Kato et al, 2000).
Other Phenotypes kl/kl mice have decreased insulin production and increased insulin sensitivity (Utsugi et al, 2000).
HomologsR.n. KLOTHO
M.m. betaKLOTHO
Primary ReferenceKuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., and Nabeshima, Y. I. (1997). Mutation of the mouse klotho gen [Abstract]
Other ReferencesKato, Y., Arakawa, E., Kinoshita, S., Shirai, A., Furuya, A., Yamano, K., Nakamura, K., Iida, A., Anazawa, H., Koh, N., Iwano, A., Imura, A., Fujimori, T., Kuro-o, M., Hanai, N., Takeshige, K., and Nabeshima, Y. (2000). Establishment of the anti-Klotho mo [Abstract]
Utsugi, T., Ohno, T., Ohyama, Y., Uchiyama, T., Saito, Y., Matsumura, Y., Aizawa, H., Itoh, H., Kurabayashi, M., Kawazu, S., Tomono, S., Oka, Y., Suga, T., Kuro-o, M., Nabeshima, Y., and Nagai, R. (2000). Decreased insulin production and increased insulin [Abstract]
Relevant LinksJAX:
KeywordsM. musculus, mouse, insulin, brain, kidney, premature aging