InterventionKinetin dietary supplementation
Alternate Name
OrganismZaprionus paravittiger
Aging PhenotypeLife-span extension
Allele TypeN/A
Strainunknown
DescriptionDietary supplementation with kinetin slows aging and increases lifespan in fruitfly (Sharma et al., 1995). Kinetin also delays onset of aging phenotypes in cultured human fibroblasts (Rattan and Clark, 1994).
Gene FunctionPlant growth hormone that retards senescence in plants (Srivastava and Atkin, 1968).
Other PhenotypesKinetin treatment can also slow development of larval and pupal insects. Increased longevity is accompanied by reduced fecundity and enhanced catalase activity (Sharma et al., 1997).
HomologsN/A
Primary ReferenceSharma, S. P., Kaur, P., and Rattan, S. I. (1995). Plant growth hormone kinetin delays ageing, prolongs the lifespan and slows down development of the fruitfly Zaprionus paravittiger. Biochem Biophys Res Commun 216, 1067-71. [Abstract]
Other ReferencesRattan, S. I., and Clark, B. F. (1994). Kinetin delays the onset of ageing characteristics in human fibroblasts. Biochem Biophys Res Commun 201, 665-72. [Abstract]
Sharma, S. P., Kaur, J., and Rattan, S. I. (1997). Increased longevity of kinetin-fed Zaprionus fruitflies is accompanied by their reduced fecundity and enhanced catalase activity. Biochem Mol Biol Int 41, 869-75. [Abstract]
Srivastava, B. I., and Atkin, R. K. (1968). Effect of second-leaf removal or kinetin treatment on the nucleic acid metabolism of senescing first seedling leaf of barley. Biochem J 107, 361-6. [Abstract]
Relevant Linksnone
Keywordsfruitfly, humans, oxidative stress, Zaprionus, paravittiger, fly, dietary supplementation