OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainBristol N2; N2 rrf-3(pk 1426)
DescriptionIncreased dosage of ins-1 under its own promoter as well as a heat shock promoter increases life span by 25% (Pierce et al. 2001). Can also enhance the life span extension of a daf-2 mutant (Pierce et al. 2001).
ins-1 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of ins-1 increases life-span by 20%.
Gene FunctionInsulin like protein.
Other PhenotypesOverexpression of ins-1 also causes an increase in dauer formation (Pierce et al. 2001). Can also enhance dauer formation of a daf-2 mutant (Pierce et al. 2001).
Primary ReferencePierce, S. B., Costa, M., Wisotzkey, R., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D. M., Pasquinelli, A. A., Liu, L. X., Doberstein, S. K., and Ruvkun, G. (2001). Regulation of DAF-2 receptor signaling by human i [Abstract]
Other ReferencesNone.
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Relevant LinksWormBase:
Keywordsmetabolism, insulin, signaling, dauer, Caenorhabditis, elegans, worm, dauer