OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainBristol N2
DescriptionExpression of human insulin under an inducible heat shock promoter increases worm life span by 25% (Pierce et al. 2001). Can also enhance the life span extension of a daf-2 mutant (Pierce et al. 2001).
Gene FunctionHuman insulin.
Other PhenotypesN/A
Primary ReferencePierce, S. B., Costa, M., Wisotzkey, R., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D. M., Pasquinelli, A. A., Liu, L. X., Doberstein, S. K., and Ruvkun, G. (2001). Regulation of DAF-2 receptor signaling by human i [Abstract]
Other ReferencesNone.
Relevant LinksNone.
Keywordsmetabolism, insulin, signaling, dauer, Caenorhabditis, elegans, worm, dauer, human, Homo, sapiens