OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionInRE19/InRp5545 transheterozygous females show an 85% increase in life span (Tatar et al., 2001). No significant change in life span is reported in male animals. Other allelic combinations of InR produced wild type or shortened life span. InrGC25/InrE19 transheterozygous animals are short lived and show an elevated rate of age-independent mortality (Clancy et al., 2001)
Gene FunctionInsulin/IGF receptor.
Other PhenotypesHeterozygous animals form dwarfs (Clancy et al., 2001; Tatar et al., 2001).
HomologsS.c. CDC15, PHO85
C.e. daf-2
D.m. Inr, sev
R.n. Ig1r, Insr
M.m. Ig1r, Insr
Primary ReferenceTatar, M., Kopelman, A., Epstein, D., Tu, M. P., Yin, C. M., and Garofalo, R. S. (2001). A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-10. [Abstract]
Other ReferencesNone.
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-6. [Abstract]
Relevant LinksFlyBase:
KeywordsDrosophila, melanogaster, fly, insulin, signaling