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| | Name | Indy |
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| Organism | Drosophila melanogaster |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | unknown |
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| Description | Flies heterozygotic for a disruption have extended lifespan (mean 87-92% longer, max 45% longer). Homozygotes for the disruption show only 10-20% increase in mean lifespan (Rogina et al., 2000). |
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| Gene Function | Unknown. Homologous to mammalian sodium dicarboxylate cotransporter (Rogina et al., 2000). |
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| Other Phenotypes | None. |
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| Homologs | D.m. Indy-2 (AE003728)
R.n. SDCT1, SDCT2
H.s. hNaDC-1
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| Primary Reference | Rogina, B., Reenan, R. A., Nilsen, S. P., and Helfand, S. L. (2000). Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290, 2137-40. [Abstract]
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| Other References | None.
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| Relevant Links |
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FlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0036816
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LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=40049
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| Keywords | Drosophila, fly, D. melanogaster, caloric restriction, metabolism |
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