NameIndy
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
Strainunknown
DescriptionFlies heterozygotic for a disruption have extended lifespan (mean 87-92% longer, max 45% longer). Homozygotes for the disruption show only 10-20% increase in mean lifespan (Rogina et al., 2000).
Gene FunctionUnknown. Homologous to mammalian sodium dicarboxylate cotransporter (Rogina et al., 2000).
Other PhenotypesNone.
HomologsD.m. Indy-2 (AE003728)
R.n. SDCT1, SDCT2
H.s. hNaDC-1
Primary ReferenceRogina, B., Reenan, R. A., Nilsen, S. P., and Helfand, S. L. (2000). Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290, 2137-40. [Abstract]
Other ReferencesNone.
Relevant LinksFlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0036816
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=40049
KeywordsDrosophila, fly, D. melanogaster, caloric restriction, metabolism