OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionDeletion extends lifespan about 50% (Lin et al., 2000).
Gene FunctionHexokinase, catalyzes addition of phosphate to glucose to make glucose-6-phosphate.
Other PhenotypesDeletion of HXK2 increases oxygen consumption (Lin et al., 2002). hxk2 mutants have a transcriptional profile that significantly resembles calorically restricted cells and cells overexpressing HAP4.
HomologsS.c. HXK1, GLK1, YDR516
S.p. hxk1, hxk2
C.e. F14B4.2, H25P06.1
D.m. CG3001, CG5443, CG8094
M. musculus: HK1, HK2, GK
H. sapiens: HK1, HK2, HK3, GCK
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesLin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P. A., Culotta, V. C., Fink, G. R., and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-8. [Abstract]
Relevant LinksSGD:
Keywordsmetabolism, caloric restriction, kinase, yeast, replicative senescence, Saccharomyces cerevisiae