NameHuman Sod1
OrganismMus musculus
Aging PhenotypeNo effect on life-span
Allele TypeOverexpression
StrainCD1, C57BL/6J
DescriptionUbiquitous overexpression of Sod1 does not extend life span in mice (Huang et al, 2000). Homozygous transgenic mice with two- to five-fold overexpression of Sod1 in various tissues showed a slight reduction in life span (Huang et al, 2000). Hemizygous transgenic mice, with 1.5- to 3-fold overexpression of Sod1 showed no difference in life span compared with nontransgenic littermate controls (Huang et al, 2000).
Gene FunctionSod1 codes for Cu,Zn superoxide dismutase, which protects against the superoxide radical, O2- , converting it to hydrogen peroxide, which is reduced further by glutathione peroxidase or by catalase (Gurney et al, 1994).
Other PhenotypesTransgenic mice with a mutant human Sod1 transgene develop neuronal cytoskeletal lesions resembling the human amyotrophic lateral sclerosis (ALS) phenotype (Tu et al, 1996).
Transgenic mice overexpressing Sod1 (and having 3.1-fold higher cellular Cu,Zn SOD activity in the brain) have reduced infarct size following experimental cerebral ischemia (Kinouchi et al, 1991)
HomologsS.c. SOD1
S.p. sod1
C.e. C15F1.7, ZK430.3, sod-4
D.m. sod, CG9027, CG17753
R.n. Sod1, Sod3
M.m. Ccsd, Sod3
H.s. SOD1, CCS, SOD3
Primary ReferenceHuang, T. T., Carlson, E. J., Gillespie, A. M., Shi, Y., and Epstein, C. J. (2000). Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci 55, B5-9. [Abstract]
Other ReferencesGurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H. X., and et al. (1994). Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Sci [Abstract]
Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH. (1991)
Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A. 88, 11158-62. [Abstract]
Tu PH, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, Lee VM. (1996) Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad S [Abstract]
Relevant LinksJAX: http://www.informatics.jax.org
Keywordsneurons, oxidative stress, mouse, M. musculus