|Intervention||Human Growth Hormone Therapy|
|Aging Phenotype||No effect on life-span|
|Description||Mice were treated with recombinant human growth hormone beginning at 18 months of age (Kalu et al, 1998). There was no significant effect on median life span, 10th percentile life span, or maximum life span, compared to solvent vehicle treatment. Similar observations were seen in male and female F344 rats, even when the dose of GH was up to 1 mg/kg body weight twice a week (Kalu et al, 1998).|
|Gene Function||Growth hormone.|
|Other Phenotypes||GH therapy at 50 mcg/kg body weight three times per week reversed the age-related decline in serum IGF-1 levels, returning it to that of 3 month old animals (Kalu et al, 1998). The prevalence of nephropathy, cardiomyopathy, leukemia, and testicular interstitial tumor, the main pathologic lesions in control animals was not altered by GH therapy (Kalu et al, 1998).|
Growth hormone therapy in rats also fails to extend life-span (Kalu et al., 1998).
|Primary Reference||Kalu, D. N., Orhii, P. B., Chen, C., Lee, D. Y., Hubbard, G. B., Lee, S., and Olatunji-Bello, Y. (1998). Aged-rodent models of long-term growth hormone therapy: lack of deleterious effect on longevity, J Gerontol A Biol Sci Med Sci 53, B452-63. [Abstract]|
|Keywords||Mus musculus, mouse, cancer|