NameHSP104
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainYPK9
DescriptionDeletion of HSP104 shortened mean lifespan by 14% (Shamaet al., 1998).
Exposure of cells to transient sub-lethal heat stress extended mean lifespan by 12% while decreasing maximum lifespan by 14% (Shama, et al., 1998). This effect was not observed in an HSP104 null strain (Shama, et al., 1998). Overexpression of HSP104 driven by GAL promoter was insufficient to extend lifespan (Shama, Lai, et al., 1998).
Gene FunctionHSP104 codes for a heat shock protein required for induced thermotolerance and resolublizing aggregates of denatured proteins (http://www.proteome.com/databases/YPD/reports/HSP104.html)
Other PhenotypesA null mutant in HSP104 is viable but displays reduced high temperature survival (Lindquist and Kim, 1996). Overproduction of Hsp104p is sufficient to induce thermotolerance (Lindquist and Kim, 1996).
HomologsS.c. HSP78, YNL218
S.p. Spbc16d10.08c, Spbc4f6.17c
C.e. C24B5.2
D.m. 84H4.1:EG:84H4.1
R.n: RN.37542
M.m. SKD3, RUVBL2, SKD1
H.s. RUVBL2, SKD1
Primary ReferenceShama, S., Lai, C. Y., Antoniazzi, J. M., Jiang, J. C., and Jazwinski, S. M. (1998). Heat stress-induced life span extension in yeast. Exp Cell Res 245, 379-88. [Abstract]
Other ReferencesLindquist, S., and Kim, G. (1996). Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. Proc Natl Acad Sci U S A 93, 5301-6. [Abstract]
Relevant LinksYPD: http://www.proteome.com/databases/YPD/reports/HSP104.html
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=HSP104
Keywordsyeast, replicative senescence, Saccharomyces cerevisiae, heat shock