OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion has no effect on wild type life-span in the short-lived strain YSK771 (Kim et al., 1999). Deletion suppresses the short life-span of a SIR3 mutant (Kim et al., 1999).
Gene FunctionHistone Deacetylase A
Other PhenotypesNull mutation results in increased telomeric silencing and increased histone acetylation (Rundlett et al., 1996).
HomologsS.c. RPD3, HOS1, HOS2p, HOS3p
S.p. hda1, clr, clr3
C.e. F41H10.6, C10E23, Y51H1A.5, F43G6.4, R06C1.1, hda-2, hda-1
D.m. HDAC2, CG1770, Rpd3, CG2128, HDAC3, CG10899
M.m. Mm.29854, Mm.22665, Hdac5, HDAC7, Hdac2
Primary ReferenceKim, S., Benguria, A., Lai, C. Y., and Jazwinski, S. M. (1999). Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol Biol Cell 10, 3125-36. [Abstract]
Other ReferencesRundlett, S. E., Carmen, A. A., Kobayashi, R., Bavykin, S., Turner, B. M., and Grunstein, M. (1996). HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93, 14503-8. [Abstract]
Relevant LinksSGD:
Keywordsyeast, replicative senescence, Saccharomyces cerevisiae, telomeres, silencing, chromatin