NameHAP5
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainW303-1A
DescriptionDeletion of HAP5 shortens life span by approximately 40% (Sinclair et al., 1997). This is not a premature aging phenotype as “old” HAP5 cells do not become prematurely sterile or show other biomarkers of yeast aging (Sinclair et al., 1997).
Gene FunctionHAP complex transcription factor.
Other PhenotypesNull mutant is unable to grow on nonfermentable carbon source (McNabb et al., 1995)
HomologsS.c. BUR6
S.p. php5, Spac17g8.03c
C.e. F23F1.1, F40F9.7
D.m. CG3075, CG11301, CG15736
R.n. NFYC
M.m. NFYC
H.s. NFYC, P12, CHRAC15
Primary ReferenceSinclair, D. A., Mills, K., and Guarente, L. (1997). Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277, 1313-6. [Abstract]
Other ReferencesMcNabb, D. S., Xing, Y., and Guarente, L. (1995). Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9, 47-58. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=HAP5
YPD: http://www.proteome.com/databases/YPD/reports/HAP5.html
Keywordssterility, transcription factor, yeast, replicative senescence, Saccharomyces cerevisiae