OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function extends life span and slows growth (Lakowski and Hekimi, 1996).
Gene FunctionNot cloned.
Other PhenotypesPost-embryonic growth rate greatly reduced. Mutant has increased resistance to heat-shock and tends to avoid bacterial lawn (Lakowski and Hekimi, 1996).
Primary ReferenceLakowski, B., and Hekimi, S. (1996). Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-3. [Abstract]
Other ReferencesNone.
Relevant LinksWormBase:
Keywordsmetabolism, Caenorhabditis, elegans, worm, heat shock , stress resistance