OrganismPodospora anserina
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionIn GRISEA loss of function mutant, senescence is delayed two-fold (Osiewacz and Nuber, 1996).
Gene FunctionGRISEA codes for a copper modulated transcription factor involved in control of cellular copper homeostasis (Osiewacz and Nuber, 1996).
Other PhenotypesMutant has altered morphology and defects in formation of female gametangia (Borghouts et al., 1997).
HomologsS.c. MAC1, ACE1
N.c. AMT1
Primary ReferenceOsiewacz, H. D., and Nuber, U. (1996). GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence, Mol Gen Genet 252, 115-24. [Abstract]
Other ReferencesBorghouts, C., Kimpel, E., and Osiewacz, H. D. (1997). Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea, Proc Natl Acad Sci U S A 94, 10768-73. [Abstract]
Relevant LinksN/A
KeywordsPodospora anserina, metabolism, transcription factor