NameGPR1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainPSY316
DescriptionDeletion extends lifespan by about 50% (Lin et al., 2000).
Gene FunctionG-protein coupled receptor that interacts with Gpa2p and regulates cAMP-PKA signaling pathway (Xue et al., 1998).
Other Phenotypesnone
HomologsS.c. DCP2, YIL105
S.p. Spbc26h8.09c, git3
C.e. Y113G7B.12, C43D7.4
D.m. CG5792
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesXue, Y., Batlle, M., and Hirsch, J. P. (1998). GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway. Embo J 17, 1996-2007. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=gpr1
YPD: http://www.proteome.com/databases/YPD/reports/GPR1.html
Keywordscaloric restriction, metabolism, signaling, yeast, replicative senescence, Saccharomyces cerevisiae