NameGPA2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainPSY316
DescriptionDeletion increases lifespan by about 50% (Lin et al., 2000).
Gene FunctionG-protein alpha subunit (Isshiki et al., 1992), acts in parallel to Ras pathway to activate adenylate cyclase (Columbo et al., 1998).
Other Phenotypesnone
HomologsS.c. GPA1, CIN4, ARF3
S.p. gpa2, gpa1
C.e. GOA-1, ODR-3, GPA-7
D.m. G-OALPHA47A, G-OALPHA65A
M.m. GNAO, GNAT2, GNAT1
H.s. GNAI1, GNAO1, GNAT2
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesIsshiki, T., Mochizuki, N., Maeda, T., and Yamamoto, M. (1992). Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Genes Dev 6, 2455-62. [Abstract]
Colombo, S., Ma, P., Cauwenberg, L., Winderickx, J., Crauwels, M., Teunissen, A., Nauwelaers, D., de Winde, J. H., Gorwa, M. F., Colavizza, D., and Thevelein, J. M. (1998). Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular ac [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=gpa2
YPD: http://www.proteome.com/databases/YPD/reports/GPA2.html
Keywordscaloric restriction, metabolism, signaling, replicative senescence, yeast, Saccharomyces cerevisiae