OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionGhrhr lit/lit animals have a life span that is 20% longer than wild type (Flurkey et al., 2001).
Gene FunctionGrowth hormone releasing hormone receptor.
Other PhenotypesLit homozygous animals are smaller than normal animals (Eicher et al., 1976). The pituitary of mutant mice is defective in growth hormone and prolactin (Beamer et al., 1976).
HomologsR.n. Ghrhr
Primary ReferenceFlurkey, K., Papaconstantinou, J., Miller, R. A., and Harrison, D. E. (2001). Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98, 6736-6741. [Abstract]
Other ReferencesBeamer, W. H., and Eicher, E. M. (1976). Stimulation of growth in the little mouse. J Endocrinol 71, 37-45. [Abstract]
Eicher, E. M., and Beamer, W. G. (1976). Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered 67, 87-91.
Relevant LinksJAX:
KeywordsM. musculus, mouse, growth hormone