Interventionantioxidant drug EUK-8
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN/A
DescriptionTreatment of worms with 5 mM EUK-8 extended mean and maximum life-span by about 50% (Melov et al., 2000).
In contrast to the results of Melov et al., (2000), Keaney and Gems (2003) report that treatment with 5 mM EUK-8 shortens life-span by approximately 83%. These opposing observations may be due to different methods used for administering the drug (e.g. daily vs. every-other-day treatment) and/or different compound sources.
Gene FunctionEUK-8 acts as a superoxide dismutase and catalase mimetic (Baker et al., 1998).
Other PhenotypesTreatment with EUK-8 does not affect fertility or body size (Melov et al., 2000).

EUK-8 treatment resulted in a shortened life-span in the house fly, Musca domestica (Bayne and Sohal, 2002).

HomologsN/A
Primary ReferenceMelov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., and Lithgow, G. J. (2000). Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-9. [Abstract]
Other ReferencesBaker, K., Marcus, C. B., Huffman, K., Kruk, H., Malfroy, B., and Doctrow, S. R. (1998). Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ische [Abstract]
Bayne, A. V., and Sohal, R. S. (2002). Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica. Free Radic Biol Med 32, 1229-34. [Abstract]
Keaney, M., and Gems, D. (2003). No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free radic biol med 34, 277-82. [Abstract]
Relevant LinksNone.
KeywordsCaenorhabditis, elegans, worm, oxidative stress