|Intervention||antioxidant drug EUK-8|
|Aging Phenotype||Life-span extension|
|Description||Treatment of worms with 5 mM EUK-8 extended mean and maximum life-span by about 50% (Melov et al., 2000). |
In contrast to the results of Melov et al., (2000), Keaney and Gems (2003) report that treatment with 5 mM EUK-8 shortens life-span by approximately 83%. These opposing observations may be due to different methods used for administering the drug (e.g. daily vs. every-other-day treatment) and/or different compound sources.
|Gene Function||EUK-8 acts as a superoxide dismutase and catalase mimetic (Baker et al., 1998).|
|Other Phenotypes||Treatment with EUK-8 does not affect fertility or body size (Melov et al., 2000). |
EUK-8 treatment resulted in a shortened life-span in the house fly, Musca domestica (Bayne and Sohal, 2002).
|Primary Reference||Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., and Lithgow, G. J. (2000). Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-9. [Abstract]|
|Other References||Baker, K., Marcus, C. B., Huffman, K., Kruk, H., Malfroy, B., and Doctrow, S. R. (1998). Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ische [Abstract]|
Bayne, A. V., and Sohal, R. S. (2002). Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica. Free Radic Biol Med 32, 1229-34. [Abstract]
Keaney, M., and Gems, D. (2003). No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free radic biol med 34, 277-82. [Abstract]
|Keywords||Caenorhabditis, elegans, worm, oxidative stress|