Interventiongerm line ablation
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainBristol N2, several other strains
DescriptionGerm line ablation extends life span by up to 60% (Hsin and Kenyon, 1999). This life span extension requires daf-16. Germ line ablation in combination with a daf-2 mutation results in a synergistic life span extension of up to 400%.
Gene FunctionN/A
Other PhenotypesNone.
Primary ReferenceHsin, H., and Kenyon, C. (1999). Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-6. [Abstract]
Other ReferencesNone.
Relevant LinksNone.
KeywordsCaenorhabditis, elegans, worm, insulin, signaling