NameGAL83
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainS288C
DescriptionDeletion has no effect on life span (Ashrafi et al., 2000).
Gene FunctionRequired for SNF1 complex formation (Jiang and Carlson, 1997).
Other PhenotypesNull mutant has no obvious phenotype (Schmidt and McCartney, 2000).
HomologsS.c. SIP2, SIP1
S.p. Spcc1919.03c
C.e. Y47D3A.15, F55F3.1
D.m. CG8057
R.n. RN.3619
H.s. PRKAB2, PRKAB1
Primary ReferenceAshrafi, K., Lin, S. S., Manchester, J. K., and Gordon, J. I. (2000). Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14, 1872-85. [Abstract]
Other ReferencesJiang, R., and Carlson, M. (1997). The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol Cell Biol 17, 2099-106. [Abstract]
Schmidt, M. C., and McCartney, R. R. (2000). beta-subunits of Snf1 kinase are required for kinase function and substrate definition. Embo J 19, 4936-43. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=gal83
YPD: http://www.proteome.com/databases/YPD/reports/GAL83.html
Keywordsreplicative senescence, Saccharomyces cerevisiae, transcription factor, yeast