NameGlial Lazarillo (GLaz)
OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainNA
DescriptionLoss of function mutations in GLaz shortened life-span and decreased resistance to oxidative stress (Sanchez et al., 2006).
Gene FunctionApolipoprotein D
Other Phenotypes
HomologsR.n. APOD
M.m. APOD
H.s. APOD
Primary ReferenceSanchez, D., Lopez-Arias, B., Canal, I., Wang, X., Bastiani, M. J., and Ganfornina, M. D. (2006). Loss of Glial Lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol 16, 680-686.
Other ReferencesWalker, D. W., Muffat, J., Rundel, C., and Benzer, S. (2006). Overexpression of a Drosophila homolog of Apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol 16, 674-678.
Relevant Links
KeywordsAlzheimer disease, oxidative stress, apoptosis