NameGlial Lazarillo (GLaz)
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
Straindaughterless (da-GAL4) x EP lines
DescriptionOverexpression of GLaz resulted in increased resistance to hyperoxia(100% O2) as well as a 29% extension of life-span under normoxia (Walker et al., 2006).
Gene FunctionApolipoprotein D
Other PhenotypesDecreased expression of GLaz results in shortened life-span (Sanchez et al., 2006).
HomologsR.n. APOD
Primary ReferenceWalker, D. W., Muffat, J., Rundel, C., and Benzer, S. (2006). Overexpression of a Drosophila homolog of Apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol 16, 674-678.
Other ReferencesSanchez, D., Lopez-Arias, B., Canal, I., Wang, X., Bastiani, M. J., and Ganfornina, M. D. (2006). Loss of Glial Lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol 16, 680-686.
Relevant Links
KeywordsAlzheimer disease, oxidative stress, starvation