NameURE2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainBY4742
DescriptionDeletion of URE2 increases yeast replicative life-span by approximately 38% (Kaeberlein et al., 2005).
Gene FunctionNegative regulator of the nitrogen responsive transcription factor Gln3.
Other Phenotypes[URE3] is a prion of URE2.
Homologs
Primary Reference
Other ReferencesKaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 119 [Abstract]
Relevant LinksUWAging: http://www.uwaging.org/ellison
SGD: http://db.yeastgenome.org/cgi-bin/locus.pl?locus=ure2
Keywordsnutrients, calorie restriction, caloric, yeast, genome-wide