NameROM2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainBY4742
DescriptionDeletion of ROM2 increases yeast replicative life-span by approximately 38% (Kaeberlein et al., 2005).
Gene FunctionRho GTPase upstream of protein kinase C
Other Phenotypes
HomologsS.c. ROM1
Primary Reference
Other ReferencesKaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 119 [Abstract]
Relevant LinksUWAging: http://www.uwaging.org/ellison
SGD: http://db.yeastgenome.org/cgi-bin/locus.pl?locus=rom2
Keywordsnutrients, calorie restriction, caloric, yeast, genome-wide