NameIDH2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainBY4742
DescriptionDeletion of IDH2 increases yeast replicative life-span by approximately 30% (Kaeberlein et al., 2005).
Gene FunctionIsocitrate dehydrogenase.
Other Phenotypes
HomologsS.c. IDH1
S.p. Glu2, Glu3
C.e. F43G9.1
D.m. CG12233, CG32026
R.n. IDH3A
M.m. IDH3A
H.s. IDH3A
Primary Reference
Other ReferencesKaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 119 [Abstract]
Relevant LinksUWAging: http://www.uwaging.org/ellison
SGD: http://db.yeastgenome.org/cgi-bin/locus.pl?locus=idh2
Keywordsnutrients, calorie restriction, caloric, yeast, genome-wide