NameRPL31A
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainBY4742
DescriptionDeletion of RPL31A increases yeast replicative life-span by approximately 35% (Kaeberlein et al., 2005).
Gene FunctionRibosomal protein of the large subunit.
Other Phenotypes
HomologsS.c. RPL31B
S.p. Rpl31
C.e. RPL-31
D.m. RPL31
R.n. RPL31
M.m. RPL31
H.s. RPL31
Primary Reference
Other ReferencesKaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 119 [Abstract]
Relevant LinksUWAging: http://www.uwaging.org/ellison
SGD: http://db.yeastgenome.org/cgi-bin/locus.pl?locus=rpl31a
Keywordsribosome, translation, nutrients, calorie restriction, caloric, yeast, genome-wide