OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainBY4742; PSY316AT
DescriptionDeletion of TOR1 increases replicative life-span by approximately 20% (Kaeberlein et al., 2005). This life-span extension is indepdent of Sir2 and additive with deletion of Fob1. Calorie restriction of tor1 mutants does not further extend life span.
Gene FunctionNutrient- and growth factor-responsive PI3-like kinase.
Other PhenotypesMutation in TOR proteins has been reported to increase life-span in both worms and flies.
HomologsS.p. Tor2
S.c. Tor2
C.e. let-363
D.m. TOR
R.n. FRAP1
M.m. mTOR (FRAP1)
H.s. FRAP1
Primary Reference
Other ReferencesKaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 119 [Abstract]
Relevant LinksUWAging:
Keywordsnutrients, kinase, calorie restriction, caloric restriction, genome-wide