OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
Strainmultiple backgrounds
DescriptionExpression of a dominant-negative allele of dmp53 specifically in adult neurons increases life-span by approximately 15% in flies (Bauer et al., 2005)
Gene FunctionOrtholog of a mammalian tumor suppressor.
Other PhenotypesLife-span extension by expression of DN-dmp53 is not additive with life-span extension from calorie restriction.
Primary ReferenceBauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M., and Helfand, S. L. (2005). Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol 15, 2063-2068.
Other References
Relevant Links
Keywordsapoptosis, stress, cancer