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| | Name | Dmp53 |
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| Organism | Drosophila melanogaster |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Overexpression |
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| Strain | multiple backgrounds |
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| Description | Expression of a dominant-negative allele of dmp53 specifically in adult neurons increases life-span by approximately 15% in flies (Bauer et al., 2005) |
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| Gene Function | Ortholog of a mammalian tumor suppressor. |
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| Other Phenotypes | Life-span extension by expression of DN-dmp53 is not additive with life-span extension from calorie restriction. |
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| Homologs | |
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| Primary Reference | Bauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M., and Helfand, S. L. (2005). Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol 15, 2063-2068.
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| Other References | |
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| Relevant Links | |
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| Keywords | apoptosis, stress, cancer |
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