NamedSIR2
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainMixed genotype
DescriptionOverexpression of dSIR2 increases median life-span by 40-60% (Rogina et al., 2004).
Gene FunctionProtein deacetylase
Other PhenotypesIncreased expression of Sir2-family members has also been shown to increase life-span in yeast (Kaeberlein et al., 1999) and worms (Tissenbaum et al., 2001).
HomologsS.c. SIR2, HST1, HST2, HST3, HST4
C.e. Sir-2.1, F46G10.3, F46G10.7, C06A5.3
D.m. CG6284, CG3187
M.m. SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6
H.s. SIRT1, SIRT3, SIRT2, SIRT5, SIRT4
Primary ReferenceRogina, B., and Helfand, S. L. (2004). Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 101, 15998-16003. [Abstract]
Other ReferencesKaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-2580. [Abstract]
Tissenbaum, H. A., and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230. [Abstract]
Relevant LinksEntrezGene: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=34708
FlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?PFgn0024291
Keywordscaloric restriction, calorie restriction, CR,