NameLET-60
OrganismCaenorhabditis elegans
Aging PhenotypeN/A
Allele TypeN/A
StrainN2
DescriptionAn activated allele of LET-60 (n1046gf)resulting in increased RAS activity enhances the long lifespan of daf-2 mutant animals, while decreased RAS activity partially suppresses the long life-span caused by mutation of daf-2 (Nanji et al., 2005).
Gene FunctionRAS-like GTPase.
Other PhenotypesIncreased RAS activity has also been reported to affect both chronological and replicative life span in yeast,however the magnitude and direction appear to be strain specific (Sun et al., 1994; Fabrizio et al., 2003; Kaeberlein et al., 2005)
HomologsS.c. Ras1, Ras2, ...
S.p. Ras1, Rhb1, Ypt2, ...
C.e. RAP-1, Y53G8AR.F, RAS-2, ...
D.m. RAS85D, RAS64B, ...
R.n. KRAS2, NRAS, HRAS, ...
M.m. KRAS, HRAS1, NRAS, ...
H.s. HRAS, NRAS , KRAS, ...
Primary ReferenceNanji, M., Hopper, N. A., and Gems, D. (2005). LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans. Aging Cell 4.
Other ReferencesKaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126, 491-504. [Abstract]
Sun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-18645. [Abstract]
Fabrizio, P., and Longo, V. D. (2003). The chronological life span of Saccharomyces cerevisiae. Aging Cell 2, 73-81. [Abstract]
Relevant LinksEntrez Gen: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=178104
Wormbase: http://www.wormbase.org/db/gene/gene?name=WBGene00002335;class=Gene
Keywordsmetabolism, dauer, RAS, insulin-like