OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionHeterozygous p63+/- mice have a lifespan 21.5% shorter than +/+ control animals (Keyes et al., 2005).
Gene FunctionTrascriptional activator and repressor.
Other PhenotypesThe decreased longevity of p63+/- mice was almost identical to that observed for p53+/m mice, a mouse model in which enhanced p53 activity provided resistance to spontaneous tumors while simultaneously accelerating the aging process (Tyner et al. 2002).
p63+/- mice were not susceptible to spontaneous tumors (Keyes et al., 2005).
HomologsD.m. p53
R.n. TRP63, TP53
M.m. TRP73, TRP53
H.s. TRP73, TP73, TP53
Primary ReferenceKeyes, W. M., Wu, Y., Vogel, H., Guo, X., Lowe, S. W., and Mills, A. A. (2005). p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev. [Abstract]
Other ReferencesTyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53. [Abstract]
Relevant LinksEntrez Gen:
Keywordscancer, apoptosis, senescence, accelerated aging