Nametub-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainN2
DescriptionMutation of tub-1 (alleles nr2004 and nr2044) results in a 20-25% increase in life-span (Mukhopadhyay et al., 2005). Life-span extension by tub-1 mutation is Daf-16 dependent.
Gene Function
Other PhenotypesMutation of tub-1 promotes increased fat accumulation (Mukhopadhyay et al., 2005).
Homologs
Primary ReferenceMukhopadhyay, A., Deplancke, B., Walhout, A. J. M., and Tissenbaum, H. A. (2005). C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metab 2, 1-8.
Other References
Relevant LinksEntrezGene: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=174312
WormBase: http://www.wormbase.org/db/gene/gene?name=WBGene00006655&class=Gene
Keywordsfat, metabolism, diabetes, insulin